I just bought the 4 mini and I have the same question.
I copied all of the files/folders that came pre-loaded on my 4 mini to my computer. I'm guessing it's safe to delete them all from the 4 mini. The only reason I can think of to keep them on the 4 mini is if I ever want to install the Maxtor software on another computer. Please correct me if I'm wrong.
I'm thinking about creating a single folder on my 4 mini and putting all of the pre-loaded files/folders in there, just to reduce the clutter.
Any thoughts or advice?